Effect of hpmc e15 lv premium polymer on release profile and compression characteristics of chitosan pectin colon targeted mesalamine matrix tablets and in vitro study on effect of ph impact on the drug release profile. Pdf effect of different viscosity grades of hpmc on drug release. Matrix tablets prepared using hpmc on contact with aqueous fluids gets. It is very suitable to use as a retardant material in cr matrix tablets, as it is nontoxic and easy to handle 5. Effect of hydroxypropyl methylcellulose and ethyl cellulose content. Here mechanism of gelation is ion depependent 19 liu z.
When hpmc polymer is exposed to aqueous medium, it undergoes rapid. Guar gum, xanthan gum, and hpmc can define release. Characterization of pharmaceutical polymers by hplc and gpc. Design, characterization and in vitro evaluation of hpmc. Effect of drugpolymer interactions through hypromellose. Interaction between nonionic polymer hydroxypropyl methyl cellulose hpmc and cationic geminiconventional surfactants. The results showed that these polymers slowed down the release of diltiazem hcl from the. Drug release was analysed according to various release kinetic models. Hydroxypropyl methylcellulose, hpmc polymer powder for. Properties of hpmc hydroxypropyl methylcellulose hydroxypropyl methylcellulose is a nonionic cellulose ether, in the appearance of white powder, odorless and tasteless.
Swellable systems are also retained because of their mechanical properties. Hydrophilic polymer matrix systems are widely used in oral controlled drug delivery because of their flexibility to obtain a desirable drug release profile, cost effectiveness, and broad regulatory acceptance. Oem factory for hydroxypropyl methyl cellulose hpmc. The polymer is judiciously combined with the drug or other active lecturer, 3354 09 07 2011 revised on. Polymer properties and characterization sciencedirect. Firefighting measures suitable extinguishing media. Redispersible polymer powder is mainly applied for the dry mixed mortar of the construction industry, and is the important additive of dry mixed mortar. Sodium carboxymethyl cellulose manufacturers and suppliers. Texture profile and viscosity of hmhpmcbased gels were compared with a commercial gel and all the rheological data obtained from the experiments confirm the suitability of these hmhpmcbased gels for use as a topical drug. As the single rateretarding polymer, xanthan gum retarded release over 24 h and the higuchi model best fit the data. The results indicated that the entrapment efficiency ee, as well as carbamazepine release profile, depended on polymeric composition and drug polymer ratios of the microspheres prepared.
On the basis of results, it was found that the profile of f sustained release dosage formulations by direct compression processes are presently synthetic or synthetic in nature. Generally, an optimum content of hpmc in the tablet is at least 20%. Out of the chosen polymers as hpmc k15m, sodium alginate. Both types of examples exist in use, with selfassociation of a hydrophobically modified polymer 7 reflecting the former case, while the interaction of xanthan and locust bean gum or sodium carboxymethyl cellulose and hydroxyethyl cellulose are examples of the latter. Hypromellose hpmc is a versatile controlled release polymer that has found wide spread adoption in controlled release dosage forms.
Hypromellose inn, short for hydroxypropyl methylcellulose hpmc, is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlleddelivery component in oral medicaments, found in a variety of commercial products. Highly water soluble drugs require higher amounts of hpmc in the tablet. Ofloxacin is drug and carbopol 940, hpmc are used as polymer. When hpmc polymer is exposed to aqueous medium, it.
Vivapharm hpmc, hypromellose, is a cellulosebased polymer for film coating, wet granulation, and hard capsule manufacturing. Effect of hpmc e15 lv premium polymer on release profile. The best entrapment efficiencies were obtained when chitosan of low. It is soluble in water, most polar organic solvents, and the appropriate proportion of ethanolwater, propanol water and dichloroethane, but insoluble in diethyl ether. The current paper was an attempt to design a sustained release dosage form using various grades of hydrophilic polymers, hypromellose hydroxylpropyl methylcellulose hpmc k15m, hpmc k100m and hpmc k200m and polyacrylate polymers, eudragit rl100 and eudragit rs100 with or without incorporating ethyl cellulose on a matrixcontrolled drug delivery system of metformin. The influence of hpmc viscosity and %hpc content as frc parameter on the release of highly soluble drug from hydrophilic matrix tablets. Increase in concentration of hpmc may result in increase in the tortuosity or gel strength of the polymer. Herein, we demonstrate that the punchsticking propensity of a highly sticky api, celecoxib cel, can be effectively reduced by spherical crystallization enabled by a polymer assisted quasiemulsion solvent diffusion qesd.
The company mainly produces and sells huamao as well as sanwei two major brand products. Formulation and design of sustained release matrix tablets. Hpmc, a semisynthetic derivative of cellulose, is a swellable and hydrophilic polymer. The study of polymers used in pharmaceutical industries. It is e type 2910, meaning that its average content of methoxyl groups is 29% and its average content of hydroxypropyl groups is 10%.
The formulations were evaluated in vitro for their dissolution characteristics over a period of 8 h. Preparation materials using hpmc, its quality and stability is better than the traditional materials dextrin, starch, etc. The application of biomedical polymer material hydroxy. Hydroxypropyl methylcellulose an overview sciencedirect topics. An immediate release capsule for pharmaceutical products in hpmconly, without gelling agents. Pvp k15 nonproprietary names povidone synonyms kollidon. Effect of hpmc k4m, hpmc k15m, sodium alginate and. Generally, higher molecular weight mw grades are preferred for highly. Hypromellose, short for hydroxypropyl methylcellulose hpmc, is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlleddelivery component in oral medicaments, found in a variety of commercial products as a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin. Redispersible polymer powder has obvious functions in the dry mixed mortar. Because hpmc is a nonionic polymer, hydration and viscosity are not affec ted by the ph of either acidic 0. The functionality of polymer blends was determined using dissolution profiles, compactibility profiles and the powders compressibility index. Rheological properties of hydroxypropylmethyl cellulose.
Various drug release mechanisms used for the examination of drug release characteristics. It can improve strength and bonding force, the elastic bending strength and rupture strength of materials. If the content is below 20 %, there is a risk for initial erosion or excess dissolution in the first. A mixture of hpmc with other polymers or plasticizers is used to eliminate bridging or filling problems. This may be due to structural reorganization of hydrophilic hpmc polymer. The application of biomedical polymer material hydroxy propyl. Pvp a water soluble, synthetic polymer having good film forming nature. The dramatic changes occurred in the drug release profile and physicochemical characteristics of the pectin, chitosan matrix tablets when a premium polymer hpmc e15 lv added in the formulation design in the optimized concentration.
As a food additive, hypromellose is an emulsifier, thickening and suspending agent. Page 1 of 7 ptr0622 benecel hydroxypropylmethylcellulose. Pdf effect of different viscosity grades of hpmc on drug. Methocel is an excellent rheology modifier, binder, film former, and waterretention agent. Noveon aa1 as enhancer of hpmc as a direct compression. Capsugel vcaps plus capsules offer excellent dissolution profile with phindependent performance, low moisture content, great machinability and visual quality. Introduction polymer science polymer science or macromolecular science is a subfield of materials science concerned with polymers, primarily synthetic polymers such as plastics and elastomers. Different aspects in drug delivery 382 viscoelastic, nonionic hydrophilic polymer which is used extensively in various formulations of controlled release dosage form, as well as in ophthalmic preparations as lubricants. The formulation of the drugs in gelatinous capsules or more frequently, in tablets, using. Hpmc can form a transparent, flexible and soft thin film which can prevent the pain filtration of grease. Optimization of polymer concentration for designing of oral. This polymer is also used considerably in glossing solutions.
The eluent selected should fully solvate the polymer while minimizing nonsize exclusion effects, mainly adsorption, which would undermine reliable. Effect of hpmc k4m, hpmc k15m, sodium alginate and carbopol. It is very suitable to use as a retardant material in cr matrix tablets, as it is nontoxic and easy to. Evaluation of various grades of hydroxypropylmethylcellulose. Impact of molecular weight and molecular weight distribution. Release profile showed a tendency to foliorv anomalous nonfickian kinetics as the hpmc content was increased. Hydroxypropyl methyl cellulose hpmc, a bio polymer derivative of cellulose available in powder form, water soluble and forms films. Polymer profile suresh gyan vihar university, jaipur page 87 4. Guar gum, xanthan gum, and hpmc can define release mechanisms. Hydrophilic matrix systems designed with watersoluble polymers, such as hypromel. Formulation and comparison of in vitro release profile of. Cbz and hpmc derivatives, including hpmc, hypromellose acetate hpmca, and hypromellose succinate hpmcs, were spraydried to prepare cbzpolymer spraydried samples spds. Methocel is an excellent rheology modifier, binder, film former, and waterretention. Use dry chemical powder, water spray fog, foam or co2.
Noveon aa1 as enhancer of hpmc as a direct compression matrix. Hydroxypropyl methylcellulose hpmc belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring fig. Cellulose ethers, especially hydroxylpropyl methylcellulose hpmc, are. Some research groups have worked on the usage of swellable hpmc as the retarding polymer to sustain the release of different drugs 24.
So in the drugrelease process polymer concentration is more important and a determinant factor compared to viscosity. The particle sizing of these grades is a maximum of 8% of the dry powder retained on a 120 mesh 0. Pdf interaction between nonionic polymer hydroxypropyl. Hpmces is chosen in order to study the release profile of the drug, tramadol hcl from the monolithic matrix membranes made of hydrophilic and hydrophobic polymers respectively.
Gatifloxacin is drug and alginate, hpmc are used as polymer. Hydroxypropyl methylcellulose an overview sciencedirect. Vivapharm hpmc e15 hypromellose from jrs pharma product. Microstructures and electrical properties of hpmcpvp. Pelagia research library hydroxypropyl methylcellulose in. Hydroxypropyl methylcellulose, k100m usp grade, hydroxypropyl methylcellulose, k100m usp grade supplier, hydroxypropyl methylcellulose, k100m usp grade distributor, cas 9004653, hydroxypropyl methylcellulose, k100m usp grade manufacturer, hydroxypropyl methylcellulose, k100m usp. Sodium carboxymethylcellulose has excellent properties in terms of thickening, water retention, metabolic inertia, dispersing stability and so on, and can be used as a thickening agent, waterholding agent, adhesive, emulsifier, auxiliary suspending agent, tablet base, biological base, biological carrier, etc. One is polyvinyl alcohol pva series of products with an annual capacity of 100,000 tons. Hydroxypropyl methylcellulose, hpmc polymer powder for sale. Sodium bicarbonate has been used as the gas generating agent to assist to formulation. Hence we are reporting here the potential use of hpmcpvp blend films as a host for inorganic salts in the preparation of polymer electrolyte. While affinisol hpmc hme does not currently fall within any of the four hydroxypropyl and methoxy substitution ranges as defined by the uspepjp, subchronic testing conducted specifically on affinisol hpmc hme confirms that this polymer has a consistent toxicology profile to current compendial grades with the same maximum daily intake. It is easy to control the dissolution profile by selecting a specific grade. The increasing polymer substitution by noveon aa1 decreases drug dissolution up to 36%, increases the exponent to.
Polymer science has been the backbone for the development of new formulations for past few years and its advances have led to development of several. The increasing polymer substitution by noveon aa1 decreases drug. Polymer science and engineering have opened a new era of functional development, which. These differences in release profile for unimodal custom benecel k750 ph prm hpmc and the equivalent viscosity benecel k4mk100lv hpmc blend were further studied by examining cloud point s figure 12 of the respective polymer solutions at different ionic strengths and by measuring the gel strengths figure of hydrated matrix tablets. Out of all the formulations studies, matrix tablets containing 40% of hpmc k15m showed comparable dissolution profile to that of the marketed preparation as indicated by a similarity factor value of f2 88. Polymer profile formulation development of solid oral dosage form page 32 5. The higher viscosity of hpmc or amount of hpmc in the tablet can decrease the drug release rate. Himankar baishya, zhou yangxing, wangshengmin and lin shao hui. Reduction of punchsticking propensity of celecoxib by. Combinations of hpmc with guar or xanthan gum resulted in a higuchi release profile, revealing the dominance of the high viscosity gel formed by hpmc.
At a fixed polymer level, drug release from the higher viscosity grades. Dissolution performance and robustness of new hypromellose. Methocel cellulose ethers include methylcellulose mc or hydroxypropyl methylcellulose hpmc polymers with solubilities ranging from watersoluble to organosoluble. Hpmc stands for hydroxypropylmethylcellulose and has been widely used as tablet and capsule excipient and capsule polymer for more than 15 years.
In monolithic systems, the drug is dissolved or dispersed in the polymer system diffusion of drug from the drugpolymer matrix controls. Hydroxypropyl methylcellulose, k100m usp grade supplier. The better drug release profile was found to be with formulation f a2 with drug. The results showed that these polymers slowed down the release of diltiazem hcl from the matrices. Additionally, hpmc products are kosher, vegetariansociety and vegan certified. A wide variety of hpmc polymer options are available to you. Punchsticking during tablet compression is a common problem for many active pharmaceutical ingredients apis, which renders tablet formulation development challenging. Jawaharlal nehru technological university, hyderabad, andhra pradesh. Dec 21, 2010 combinations of hpmc with guar or xanthan gum resulted in a higuchi release profile, revealing the dominance of the high viscosity gel formed by hpmc. Effect of hydroxypropyl methylcellulose and ethyl cellulose. Effect of hpmc e15 lv premium polymer on release profile and compression characteristics of chitosan pectin colon targeted mesalamine matrix tablets and in vitro study on effect of ph impact on the drug release profile volume. The aim of the current study was to formulate fexofenadine hydrochloride loaded sustained release microspheres using hpmc k100 m cr, a release retardant hydrophilic polymer by solvent evaporation method.
Hpmc is hydrophilic water soluble, a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings. Customizing hpmc to minimize drug variability the authors evaluated the performance and robustness of controlledrelease tablets made with hpmc blends of unimodal and bimodal molecular weight distribution. Formulation and release behaviour of sustained release. American polymer standards corporation safety data sheet.
Metolose sr, usp hypromellose hpmc, is exclusively designed for a. The influence of hpmc viscosity and %hpc content as frc. Hypromellose hpmc is a controlledrelease polymer that has found widespread adoption in controlledrelease dosage forms. A seminar on hpmc and its role in pharmaceutical formulations. Cellulose content on release profile and kinetics of. Hpmc a biomedical polymer in pharmaceutical dosage forms. The hydrodynamics volume occupied by the hydrated polymer chains is larger in polymers of higher molecular weight. Cbzhpmc spd and cbzhpmca spd recrystallized within 10 days at 60 c and 0% relative humidity, whereas cbzhpmcs spd maintained its amorphous state for a longer period. Hpmc exhibits ph independent drug release profile 2. Gel permeation chromatography is an ideal technique for the determination of polymer molecular weight distribution.
Chemical structure of hydroxypropyl methylcellulose, r h. The dissolution data were fitted according to the wellknown exponential equation, which is often used to describe the drug release behaviour from polymeric systems korsmeyer et al. Hpmc, being a biodegradable polymer, has also been used to prepare biocomposites. Soluble in naoh 1 m, slightly soluble in methanol i made solid dispersion with hpmc by milling method. Empty transparent and colored capsules are vegan certified.
Hpmc grades benecel hpmc k1500 ph prm and benecel hpmc k750 ph prm with high and low mw hpmc blends of equal viscosity. Polymer profile formulation development of solid oral dosage form page 35 5. When used alone, the polymer has the tendency to bridge or fill the debossed tablet surfaces. At the same polymer content in the matrix, the drug release was most sustained with tablets prepared using hpmc k15m. American polymer standards corporation safety data sheet page 2 of 5 hydroxypropyl methylcellulose section 5. Safety hpmc is generally regarded as a nontoxic and nonirritating material, the who has not specified an acceptable daily intake for hpmc since the levels consumed were not considered to represent a hazard to. The effect of different drug loading on drug content, drug encapsulation efficiency and release of drug was monitored.
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